By comparison, a sweetener packet found on a restaurant tabletop generally contains 1,000 milligrams per packet. It only takes a very small dose of fentanyl, 2 milligrams, to be lethal.Drug traffickers are using fake pills to exploit the opioid crisis and prescription drug misuse. Fentanyl appears in fake tablets, pills, and gel capsules attempting to mimic certain prescription drugs.Illicit fentanyl now appears in powder form, and is often visually indistinguishable by law enforcement. Fentanyl has historically been marketed for end-stage cancer treatment and applied via patches on the skin.Fentanyl is approximately 100 times more powerful than morphine, the substance to which heroin metabolizes, and is commonly used as an end of life sedative or during operational anesthesia. Illicit fentanyl is a deadly synthetic opioid that is being mixed into heroin, cocaine, and other street drugs.It is the most dangerous drug threat facing our nation.

The increase in drug overdose deaths is being driven by illicit fentanyl.Of this total, approximately 66% of overdose deaths were attributable to opioids.Drug overdoses are the leading cause of death for Americans ages 18-45. This is an average of nearly 295 people per day. In 2021, 107,622 lives were lost in the United States due to a drug overdose. Discussion of opioid prevention, treatment, enforcement, and deterrence in your community should address illicit drugs and prescription drugs, as opioids in all forms are present across the nation.Fentanyl derivatives such as carfentanil, which is used to anesthetize elephants, is also being used to adulterate heroin, causing cluster overdose deaths. Fentanyl, an opioid that is practically and effectively 50 and 100 times more potent than heroin or prescription opioids, is often used to adulterate heroin, cocaine, methamphetamine and other “street drugs.” Overdose deaths often result from a user’s unwitting purchase and use of fentanyl when believing he or she is purchasing heroin or prescription pills.Opioid dependence and withdrawal is characterized by constricted nausea, mental confusion, drowsiness, severe sweats and constipation. Opioid overdose effects include severe depression of the respiratory system, potentially causing respiratory arrest, coma, and death.The effects of opioids, particularly their rewarding, euphoric effects, are accentuated most when the drugs are delivered rapidly into the brain, thereby causing users “chasing the high” to snort or inject crushed prescription pills or heroin.Opioids bind to mu-opioid receptors on the nerve cells in the brain and body to reduce pain and suppress coughs when used legitimately, but can also cause intense euphoria or intense high that can lead to dependence and/or addiction, whether the drug ingested is heroin or a legally prescribed drug.Opioids are a class of drugs that includes the illegal drug heroin as well as power pain relievers available by prescription, such as oxycodone (Oxycontin), hydrocodone (Vicodin), codeine, morphine, fentanyl, methadone, and many others.

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